Liverpool Causality Assessment Tool

Stage 1: Exclusion Criteria Assessment

Is there sufficient clinical information about the case?

Did the ADR occur after the drug was administered?

Was the drug administered?

Does the case involve a normal dose of the drug (not an overdose)?

Stage 2: Detailed Assessment of Key Elements

Is the time between drug administration and ADR onset consistent with the known pharmacokinetics of the drug?

Did the ADR improve or resolve after the drug was stopped or the dose was reduced?

Did the ADR recur when the drug was re-administered?

Are there no plausible alternative causes for the ADR (e.g. concomitant drugs, underlying disease)?

Is the ADR a known effect of the drug (as listed in an authoritative reference)?

Do laboratory test results support the diagnosis of the ADR?