The Drug-Induced Liver Injury (DILI) Causality Assessment tool provides a systematic approach to evaluating liver injury potentially caused by medications or supplements. It considers critical factors, including recent drug intake within the past six months, liver enzyme improvements after discontinuation, alternative causes such as viral hepatitis or alcohol, and whether the injury occurred within a known timeframe after drug initiation. Additionally, it assesses if the patient has previously reacted to the same or related drugs. This tool helps healthcare professionals accurately determine DILI causality, ensuring thorough evaluations and informed decisions for patient safety and effective pharmacovigilance practices.